Description
Antiserum to Human Transferrin made in goat
Transferrin is a monomeric glycoprotein found in plasma at an average concentration of 250 mg/100 ml. The specific iron-binding protein in plasma, it has a role in the transportation and distribution of iron among the body organs, in iron metabolism and prevention of iron loss via the kidneys. Stored in bone marrow as Tf-bound iron, it also possesses bacteriostatic and fungistatic activity. Clinically, decreases in transferrin are observed in congenital disorders, newborns, inflammatory diseases, hypoproteinemias and nephrotic syndrome; increases are found in pregnancy, iron-deficiency anemias, and inoculation hepatitis. Transferrin is required by all types of cells in cultures for maximal growth. It is, therefore, an important transport factor used in defined culture media.
Ref: MacGillivray, R.T.A. et al. 1982 Proc. Natl. Acad. Sci. USA. 79,2504; Rivat,C. et al. 1992 J. Chromatogr. 576,71
2013 Citations:
Enns, Caroline A., Riffat Ahmed, Jiaohong Wang, Akiko Ueno, Christal Worthen, Hidekazu Tsukamoto, and An-Sheng Zhang. "Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway." PloS one 8, no. 4 (2013): e60534.
Synonym: Human transferrin, Siderophilin