Anti Human Alpha-1-Antitrypsin

Description

Antiserum to Human Alpha-1-Antitrypsin made in goat

An acute-phase plasma protein found at 95-350 mg per 100 ml that functions as a protease inhibitor. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions.

Activity: When tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate, it is 75-100% inhibitory.Ref:
Sinden, Nicola J., and Robert A. Stockley. "Proteinase 3 activity in sputum from subjects with alpha-1-antitrypsin deficiency and COPD." European Respiratory Journal 41, no. 5 (2013): 1042-1050.

Zhu, Lei, Sari Jäämaa, Taija M. af Hällström, Marikki Laiho, Anna Sankila, Stig Nordling, Ulf‐Håkan Stenman, and Hannu Koistinen. "PSA forms complexes with α1‐antichymotrypsin in prostate." The Prostate 73, no. 2 (2013): 219-226.